Dulkadir Zeki, Chaturvedi Arvind K, Craft Kristi J, Hickerson Jeffery S, Cliburn Kacey D
Department of Aerospace Medicine, Gülhane Military Medical Academy, Eskisehir, 26020, Turkey.
U.S. Department of Transportation, Civil Aerospace Medical Institute, Federal Aviation Administration, P. O. Box 25082 (AAM-610), Oklahoma City, OK, 73125.
J Forensic Sci. 2017 Jan;62(1):164-168. doi: 10.1111/1556-4029.13257. Epub 2016 Dec 1.
Prevalence of tricyclic antidepressants (TCAs) has not been explored in pilots. The National Transportation Safety Board (NTSB) aviation accident and the Federal Aviation Administration's Civil Aerospace Medical Institute (CAMI) toxicology and medical certification databases were searched for pilots fatally injured in aviation accidents. During 1990-2012, CAMI received bio-samples of pilots from 7037 aviation accidents. Of these, 2644 cases were positive for drugs. TCAs were present in 31. TCA blood concentrations ranged from therapeutic to toxic levels. The NTSB determined that the use of drugs and ethanol as the probable cause or contributing factor in 35% (11 of 31) of the accidents. None of the 31 pilots reported the use of TCAs during their aviation medical examination. The prevalence of TCAs in aviators was less than 0.5% (31 of 7037 cases). There is a need for aviators to fully disclose the use of medications at the time of their medical examination.
尚未对飞行员中三环类抗抑郁药（TCA）的使用情况进行研究。检索了美国国家运输安全委员会（NTSB）的航空事故数据库以及美国联邦航空管理局民用航空医学研究所（CAMI）的毒理学和医学认证数据库，以查找在航空事故中遇难的飞行员信息。在1990年至2012年期间，CAMI收到了来自7037起航空事故中飞行员的生物样本。其中，2644例药物检测呈阳性。31例检测出三环类抗抑郁药。三环类抗抑郁药的血液浓度范围从治疗水平到中毒水平。NTSB认定，在35%（31起事故中的11起）的事故中，药物和乙醇的使用是可能的原因或促成因素。31名飞行员中没有一人在航空体检时报告使用过三环类抗抑郁药。飞行员中三环类抗抑郁药的使用率低于0.5%（7037例中的31例）。飞行员在体检时需要充分披露所使用的药物情况。
