Milasin J, Mićić M, Mićić S, Diklić V
Institute of Biology and Human Genetics, University of Belgrade, Yugoslavia.
Cancer Genet Cytogenet. 1989 Oct 1;42(1):135-42. doi: 10.1016/0165-4608(89)90016-2.
Cytogenetic analysis was carried out in 100 tissue specimens from 88 patients with bladder cancer. Using a direct technique of chromosome preparation, analyzable metaphases were obtained in 60 cases. Various chromosomal abnormalities, numerical as well as structural, were found. The frequencies of different marker chromosomes, with the exception of the ring chromosome, increased from grade 1 to grade 3 tumors. The average number of markers per cell was one in G1, four in G2, and eight in G3 tumors. It was possible to make a distinction between structural aberrations occurring in all histologic grades and those specific for the invasive grade 2 and grade 3 tumors.
对88例膀胱癌患者的100份组织标本进行了细胞遗传学分析。采用直接染色体制备技术，60例获得了可分析的中期分裂相。发现了各种染色体异常，包括数目异常和结构异常。除环状染色体外，不同标记染色体的频率从1级肿瘤到3级肿瘤逐渐增加。G1期肿瘤细胞中标记物的平均数量为1个，G2期为4个，G3期为8个。有可能区分所有组织学分级中出现的结构畸变与浸润性2级和3级肿瘤特有的结构畸变。
