Mićić S, Mićić M, Milasin J
Urologic Clinic, Medical Faculty of Belgrade, Yugoslavia.
Urol Int. 1988;43(4):201-4. doi: 10.1159/000281338.
Cytogenetic analysis was performed in 80 patients with bladder tumor. The mitotic activity in patients with tumor G1, G2 and G3 degree of differentiation was not significantly different among them. Most of the patients with noninvasive tumor (G1) had a diploid or nearly diploid chromosome number, but all patients with invasive (G2 and G3) tumor had polyploidy. Marker chromosomes were found in 14 patients and 9 of them developed recurrence very soon. There is a good correlation between the recurrence rate and numerical or structural chromosomal abnormalities. This study emphasizes the importance of the chromosome analysis in the evaluation of therapy and prognosis for patients with bladder tumors.
对80例膀胱肿瘤患者进行了细胞遗传学分析。肿瘤分化程度为G1、G2和G3级的患者，其有丝分裂活性在组间无显著差异。大多数非浸润性肿瘤（G1）患者的染色体数目为二倍体或近二倍体，但所有浸润性（G2和G3）肿瘤患者均有多倍体。在14例患者中发现了标记染色体，其中9例很快出现复发。复发率与染色体数目或结构异常之间存在良好的相关性。本研究强调了染色体分析在评估膀胱肿瘤患者治疗和预后中的重要性。
