Moreau Thibault, Bungener Catherine, Heinzlef Olivier, Suchet Laurent, Borgel Florent, Bourdeix Isabelle, Meite Mohamed, Rerat Karin, Chouette Isabelle
Department of Neurology, CHU Dijon, Dijon, France.
Eur Neurol. 2017;77(1-2):47-55. doi: 10.1159/000451077. Epub 2016 Dec 2.
The objective of this prospective study was to assess the changes in anxiety levels, and their relationship with coping strategies over the first four months of fingolimod treatment in patients with relapsing remitting multiple sclerosis (RRMS). Data were collected at the inclusion visit (Visit 1) and 4 months later (Visit 2). We used the Hospital Anxiety and Depression Scale (HADS) to assess the level of anxiety and the Coping Inventory for Stressful Situations scale to assess the coping strategies used when engaged with stressful situations. The HADS anxiety scores were compared between Visits 1 and 2, according to the preferred coping strategy. At Visit 1, half of the 198 patients included were considered to be anxious (doubtful or in a certain way). The same proportion preferentially used an avoidance-oriented strategy and one-third preferentially used an emotion-oriented strategy. The mean HADS anxiety score decreased significantly (p = 0.001) at Visit 2 (8.1 ± 4.0) compared to Visit 1 (8.8 ± 4.3), particularly in the group of patients who used an emotion-oriented strategy (p = 0.002). In conclusion, the initiation of fingolimod in patients with RRMS is followed by a decrease of anxiety levels which vary according to the coping strategy used.
这项前瞻性研究的目的是评估复发缓解型多发性硬化症（RRMS）患者在服用芬戈莫德治疗的前四个月中焦虑水平的变化及其与应对策略的关系。在纳入访视（访视1）时和4个月后（访视2）收集数据。我们使用医院焦虑抑郁量表（HADS）评估焦虑水平，并使用应激情况应对量表评估面对应激情况时所采用的应对策略。根据首选应对策略，对访视1和访视2时的HADS焦虑评分进行比较。在访视1时，纳入的198例患者中有一半被认为存在焦虑（可疑或某种程度上存在焦虑）。相同比例的患者优先使用回避导向型策略，三分之一的患者优先使用情绪导向型策略。与访视1时（8.8±4.3）相比，访视2时（8.1±4.0）的HADS焦虑评分显著降低（p = 0.001），尤其是在使用情绪导向型策略的患者组中（p = 0.002）。总之，RRMS患者开始使用芬戈莫德后焦虑水平会降低，且降低程度因所采用的应对策略而异。
