Fernández L E, Valiente O G, Mainardi V, Bello J L, Vélez H, Rosado A
Departamento de Bioquímica, Instituto Nacional de Oncología y Radiobiología, Havana, Cuba.
Carbohydr Res. 1989 Jul 1;190(1):77-83. doi: 10.1016/0008-6215(89)84148-5.
Cold water extraction of the red alga Gracilaria dominguensis, followed by cetyltrimethylammonium bromide fractionation, gave a highly sulfated, agar-type polysaccharide which inhibited the transplantation of Ehrlich ascites carcinoma in mice. The structure of the polysaccharide has been investigated by methylation analysis, and 1H- and 13C-n.m.r. spectroscopy, and was shown to be mainly composed of alternating (1----3)-linked beta-D-galactopyranosyl 6-sulfate and (1----4)-linked 3,6-anhydro-alpha-L-galactopyranosyl residues.
