急性病毒性肝炎、慢性活动性肝炎及结节性多动脉炎中的循环免疫复合物（作者译）

[Circulating immune complexes in acute viral hepatitis, chronic active hepatitis, and periarteritis nodosa (author's transl)].

作者信息

Hütteroth T H, Arnold W, Hopf U, Meyer zum Büschenfelde K H

出版信息

Z Gastroenterol. 1978 Jun;16(6):395-402.

Abstract

Circulating immune complexes were determined in patients with acute viral hepatitis, chronic active hepatitis and periarteriitis nodosa with the Raji cell technique. Circulating immune complexes were found in 11/18 HBsAg positive and HBsAg negative cases of acute viral hepatitis. In HBsAg positive chronic active hepatitis immune complexes were detectable in 42/43 cases but only in 1/27 HBsAg negative cases. Ten healthy HBsAg carriers demonstrated no detectable immune complexes. Using FITC conjugated antisera against HBs, HBc, and e antigen, immune complexes could not be found in any case of acute viral hepatitis or chronic active hepatitis. Elution of immune complexes from Raji demonstrated IgG, C'3 and a lack of HBsAg, HBc or e antigen. Immune complexes were present in 4/8 cases with periarteriitis nodosa. Viral components were detectable in one case.

摘要

采用拉吉细胞技术对急性病毒性肝炎、慢性活动性肝炎和结节性多动脉炎患者的循环免疫复合物进行了检测。在18例急性病毒性肝炎患者中，11例HBsAg阳性和HBsAg阴性病例检测到循环免疫复合物。在HBsAg阳性的慢性活动性肝炎患者中，43例中有42例可检测到免疫复合物，而在HBsAg阴性的27例中仅1例可检测到。10名健康的HBsAg携带者未检测到免疫复合物。使用针对HBs、HBc和e抗原的异硫氰酸荧光素偶联抗血清，在急性病毒性肝炎或慢性活动性肝炎的任何病例中均未发现免疫复合物。从拉吉细胞洗脱的免疫复合物显示有IgG、C'3，且缺乏HBsAg、HBc或e抗原。8例结节性多动脉炎患者中有4例存在免疫复合物。1例可检测到病毒成分。