Wheelock Muriah D, Harnett Nathaniel G, Wood Kimberly H, Orem Tyler R, Granger Douglas A, Mrug Sylvie, Knight David C
Department of Psychology, University of Alabama at Birmingham, Birmingham AL, USA.
Institute for Interdisciplinary Salivary Bioscience Research, University of California at Irvine, IrvineCA, USA; Johns Hopkins University School of Nursing, Johns Hopkins University Bloomberg School of Public Health, and Johns Hopkins University School of Medicine, BaltimoreMD, USA.
Front Hum Neurosci. 2016 Nov 17;10:583. doi: 10.3389/fnhum.2016.00583. eCollection 2016.
Contemporary theory suggests that prefrontal cortex (PFC) function is associated with individual variability in the psychobiology of the stress response. Advancing our understanding of this complex biobehavioral pathway has potential to provide insight into processes that determine individual differences in stress susceptibility. The present study used functional magnetic resonance imaging to examine brain activity during a variation of the Montreal Imaging Stress Task (MIST) in 53 young adults. Salivary cortisol was assessed as an index of the stress response, trait anxiety was assessed as an index of an individual's disposition toward negative affectivity, and self-reported stress was assessed as an index of an individual's subjective psychological experience. Heart rate and skin conductance responses were also assessed as additional measures of physiological reactivity. Dorsomedial PFC, dorsolateral PFC, and inferior parietal lobule demonstrated differential activity during the MIST. Further, differences in salivary cortisol reactivity to the MIST were associated with ventromedial PFC and posterior cingulate activity, while trait anxiety and self-reported stress were associated with dorsomedial and ventromedial PFC activity, respectively. These findings underscore that PFC activity regulates behavioral and psychobiological components of the stress response.
当代理论认为，前额叶皮层（PFC）功能与应激反应心理生物学中的个体差异有关。加深我们对这一复杂生物行为途径的理解，有可能为确定应激易感性个体差异的过程提供见解。本研究使用功能磁共振成像来检查53名年轻人在蒙特利尔成像应激任务（MIST）变体过程中的大脑活动。唾液皮质醇被评估为应激反应的指标，特质焦虑被评估为个体对消极情感倾向的指标，自我报告的应激被评估为个体主观心理体验的指标。心率和皮肤电导率反应也被评估为生理反应性的额外测量指标。背内侧前额叶皮层、背外侧前额叶皮层和顶下小叶在MIST期间表现出不同的活动。此外，唾液皮质醇对MIST的反应差异与腹内侧前额叶皮层和后扣带回活动有关，而特质焦虑和自我报告的应激分别与背内侧和腹内侧前额叶皮层活动有关。这些发现强调，前额叶皮层活动调节应激反应的行为和心理生物学成分。
