小鼠B细胞系中IgM和IgD的差异性内吞作用。

Differential endocytosis of IgM and IgD in murine B cell lines.

作者信息

Guarini L, Weber D A, Pernis B

机构信息

Division of Pediatric Hematology-Oncology, College of Physicians and Surgeons, Columbia University, New York, New York 10032.

出版信息

Cell Immunol. 1989 Oct 15;123(2):456-61. doi: 10.1016/0008-8749(89)90305-5.

DOI:10.1016/0008-8749(89)90305-5

PMID:2790970

Abstract

The internalization of surface immunoglobulin (Ig) by B lymphocytes is the first step in the antigen-presenting function performed by these cells. Mature B cells coexpress on their surface IgM and IgD. At this time, there is controversy over whether these two isotypes serve different functions in the antigen-presenting process. The results presented here show that the intracellular pattern of distribution of IgM and IgD after internalization is strikingly different in the B cell lines studied. These findings support the hypothesis that the role of the two Ig classes in the antigen-presenting function may be different.

摘要

B淋巴细胞对表面免疫球蛋白（Ig）的内化是这些细胞执行抗原呈递功能的第一步。成熟B细胞在其表面共表达IgM和IgD。此时，关于这两种同种型在抗原呈递过程中是否发挥不同功能存在争议。此处呈现的结果表明，在所研究的B细胞系中，内化后IgM和IgD的细胞内分布模式显著不同。这些发现支持了这两种Ig类别在抗原呈递功能中作用可能不同的假说。