Korsholm Anne-Sofie, Hvidman Helene Westring, Bentzen Janne Gasseholm, Nyboe Andersen Anders, Birch Petersen Kathrine
a The Fertility Clinic, Copenhagen University Hospital , Copenhagen , Denmark.
Gynecol Endocrinol. 2017 Apr;33(4):320-323. doi: 10.1080/09513590.2016.1259406. Epub 2016 Dec 2.
The aim of this cross-sectional study was to investigate side differences in antral follicle count (AFC) and ovarian volume in left versus right ovaries in relation to chronological and "biological" age, the latter estimated by anti-Müllerian hormone (AMH) levels. The cohort comprised 1423 women: 1014 fertile and 409 infertile. All were examined by transvaginal sonography and serum AMH. Overall the right ovary contained 8.1% more antral follicles (p = 0.002) and had 10.7% larger volume compared with the left (p < 0.001). In all AMH quartiles, the right ovarian volume was larger than the left (p ≤ 0.003). AFC was significantly higher in the right compared to the left ovary in the three upper AMH quartiles (p ≤ 0.005). The findings were similar when stratified in age quartiles. More than half (54.8%) had polycystic ovarian (PCO) morphology in at least one ovary. Of these women, 46.3% (n = 361) had PCO morphology unilateral - most frequently on the right side (27.6%) compared to the left (18.7%, p < 0.001). The consistent difference in AFC and ovarian volume found in AMH and age quartiles may be explained by presence of a larger pool of primordial follicles in the right ovary established during fetal life.
这项横断面研究的目的是调查左右卵巢的窦卵泡计数（AFC）和卵巢体积的侧别差异与实际年龄和“生物学”年龄的关系，后者通过抗苗勒管激素（AMH）水平进行估算。该队列包括1423名女性：1014名可育女性和409名不育女性。所有女性均接受经阴道超声检查和血清AMH检测。总体而言，右侧卵巢的窦卵泡比左侧多8.1%（p = 0.002），体积比左侧大10.7%（p < 0.001）。在所有AMH四分位数中，右侧卵巢体积均大于左侧（p≤0.003）。在AMH较高的三个四分位数中，右侧卵巢的AFC显著高于左侧（p≤0.005）。按年龄四分位数分层时，结果相似。超过一半（54.8%）的女性至少一侧卵巢有多囊卵巢（PCO）形态。在这些女性中，46.3%（n = 361）为单侧PCO形态——最常见于右侧（27.6%），而左侧为18.7%（p < 0.001）。在AMH和年龄四分位数中发现的AFC和卵巢体积的一致差异可能是由于胎儿期右侧卵巢中存在更大的原始卵泡池所致。
