Schmitz Randy J, Wang Hsin-Min, Polprasert Daniel R, Kraft Robert A, Pietrosimone Brian G
The University of North Carolina at Greensboro, Greensboro, NC, United States.
China Medical University, Taiwan.
Knee. 2017 Mar;24(2):217-223. doi: 10.1016/j.knee.2016.10.004. Epub 2016 Nov 30.
Establishing clinically accessible measures of cartilage health is critical for assessing effectiveness of protocols to reduce risk of osteoarthritis (OA) development and progression. Cartilage thickness is one important measure in describing both OA development and progression. The objective was to determine the relationship between ultrasound and MRI measures of cartilage thickness in the medial femoral condyle.
Mean cartilage thicknesses of the left medial femoral cartilage were measured via T1 weighted MRI and ultrasound imaging from transverse, anterior, middle, and posterior medial femoral regions in 10 healthy females (Mean±Std Dev) (1.66±0.08m, 59.5±8.3kg, 21.6±1.4years) and nine healthy males (1.80±0.08m, 79.1±6.2kg, 21.7±1.5years). Pearson correlations examined relationships between MRI and ultrasound measures. Bland-Altman plots evaluated agreement between the imaging modalities.
Transverse ultrasound thickness measures were significantly positively correlated with MRI middle (r=.67, P≤.05) and posterior thicknesses (r=.49, P≤.05) while the middle and posterior longitudinal ultrasound measures were significantly correlated to their respective MRI regions (r=.67, P≤.05 & r=.59 P≤.05, respectively). There was poor absolute agreement between correlated measures with ultrasound thickness measures being between 1.9 and 2.8mm smaller than MRI measures.
These results suggest that ultrasound may be a viable clinical tool to assess relative cartilage thickness in the middle and posterior medial femoral regions. However, the absolute validity of the ultrasound measure is called into question due to the larger MRI-based thickness measures.
Level IV.
建立临床上可获取的软骨健康测量方法对于评估降低骨关节炎（OA）发生和进展风险方案的有效性至关重要。软骨厚度是描述OA发生和进展的一项重要指标。目的是确定股骨内侧髁软骨厚度的超声测量值与MRI测量值之间的关系。
对10名健康女性（平均±标准差）（身高1.66±0.08米，体重59.5±8.3千克，年龄21.6±1.4岁）和9名健康男性（身高1.80±0.08米，体重79.1±6.2千克，年龄21.7±1.5岁），通过T1加权MRI和超声成像测量左股骨内侧软骨的平均厚度，测量部位包括股骨内侧的横向、前部、中部和后部区域。采用Pearson相关性分析来检验MRI测量值与超声测量值之间的关系。通过Bland-Altman图评估两种成像方式之间的一致性。
横向超声厚度测量值与MRI中部厚度（r = 0.67，P≤0.05）和后部厚度（r = 0.49，P≤0.05）显著正相关，而纵向超声中部和后部测量值与其各自的MRI区域显著相关（分别为r = 0.67，P≤0.05和r = 0.59，P≤0.05）。相关测量值之间的绝对一致性较差，超声厚度测量值比MRI测量值小1.9至2.8毫米。
这些结果表明，超声可能是评估股骨内侧中部和后部区域相对软骨厚度的一种可行的临床工具。然而，由于基于MRI的厚度测量值较大，超声测量的绝对有效性受到质疑。
IV级。
