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病前认知能力与社会功能及年轻男性自杀之间的关联:一项历史前瞻性队列研究。

The association between premorbid cognitive ability and social functioning and suicide among young men: A historical-prospective cohort study.

作者信息

Weiser Mark, Fenchel Daphna, Werbeloff Nomi, Goldberg Shira, Fruchter Eyal, Reichenberg Abraham, Burshtein Shimon, Large Matthew, Davidson Michael, Lubin Gad

机构信息

Department of Psychiatry, Sheba Medical Center, Ramat Gan, Israel; Department of Psychiatry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Department of Psychiatry, Sheba Medical Center, Ramat Gan, Israel.

出版信息

Eur Neuropsychopharmacol. 2017 Jan;27(1):1-7. doi: 10.1016/j.euroneuro.2016.11.015. Epub 2016 Dec 1.

Abstract

Previous studies have found associations between low cognitive ability and later completed suicide. The aim of this study was to examine the association between cognitive ability and social functioning in adolescence, and later completed suicide in a large population-based longitudinal study. Data from the Israeli Draft Board Register for 634,655 Israeli male adolescents aged 16 and 17 was linked to a causes-of-death data registry, with a mean follow-up of 10.6 years for completed suicide. Our results show that in males without a psychiatric diagnosis, both low (adjusted HR=1.51, 95% CI: 1.19-1.92) and high (adjusted HR=1.36, 95% CI: 1.04-1.77) cognitive ability, and very poor (adjusted HR=2.30, 95% CI: 1.34-3.95) and poor (adjusted HR=1.64, 95% CI: 1.34-2.07) social functioning were associated with increased risk for later completed suicide; however positive predictive values were low (PPVs=0.09% and 0.10%, for low cognitive ability and very poor or poor social functioning, respectively). No association between cognitive ability or social functioning and risk for suicide was found in males with a psychiatric diagnosis. These data do not support the clinical utility of screening for such potential predictors.

摘要

以往的研究发现低认知能力与后来的自杀死亡之间存在关联。本研究的目的是在一项基于大规模人群的纵向研究中,检验青少年认知能力与社会功能之间的关联,以及后来的自杀死亡情况。来自以色列征兵登记局的634655名16岁和17岁以色列男性青少年的数据与死因数据登记处相链接,自杀死亡的平均随访时间为10.6年。我们的结果显示,在没有精神疾病诊断的男性中,低认知能力(校正风险比=1.51,95%置信区间:1.19-1.92)和高认知能力(校正风险比=1.36,95%置信区间:1.04-1.77),以及非常差的社会功能(校正风险比=2.30,95%置信区间:1.34-3.95)和差的社会功能(校正风险比=1.64,95%置信区间:1.34-2.07)都与后来自杀死亡风险增加相关;然而,阳性预测值较低(低认知能力以及非常差或差的社会功能的阳性预测值分别为0.09%和0.10%)。在有精神疾病诊断的男性中,未发现认知能力或社会功能与自杀风险之间存在关联。这些数据不支持对这类潜在预测因素进行筛查的临床实用性。

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