帕金森病语义加工的神经生理学研究
A Neurophysiological Study of Semantic Processing in Parkinson's Disease.
作者信息
Angwin Anthony J, Dissanayaka Nadeeka N W, Moorcroft Alison, McMahon Katie L, Silburn Peter A, Copland David A
机构信息
1University of Queensland,School of Health and Rehabilitation Sciences,Brisbane,Australia.
2University of Queensland,UQ Centre for Clinical Research,Brisbane,Australia.
出版信息
J Int Neuropsychol Soc. 2017 Jan;23(1):78-89. doi: 10.1017/S1355617716000953. Epub 2016 Dec 5.
OBJECTIVES
Cognitive-linguistic impairments in Parkinson's disease (PD) have been well documented; however, few studies have explored the neurophysiological underpinnings of semantic deficits in PD. This study investigated semantic function in PD using event-related potentials.
METHODS
Eighteen people with PD and 18 healthy controls performed a semantic judgement task on written word pairs that were either congruent or incongruent.
RESULTS
The mean amplitude of the N400 for new incongruent word pairs was similar for both groups, however the onset latency was delayed in the PD group. Further analysis of the data revealed that both groups demonstrated attenuation of the N400 for repeated incongruent trials, as well as attenuation of the P600 component for repeated congruent trials.
CONCLUSIONS
The presence of N400 congruity and N400 repetition effects in the PD group suggests that semantic processing is generally intact, but with a slower time course as evidenced by the delayed N400. Additional research will be required to determine whether N400 and P600 repetition effects are sensitive to further cognitive decline in PD. (JINS, 2017, 23, 78-89).
目的
帕金森病（PD）患者的认知语言障碍已有充分记录；然而，很少有研究探讨PD患者语义缺陷的神经生理学基础。本研究使用事件相关电位来研究PD患者的语义功能。
方法
18名PD患者和18名健康对照者对书面单词对进行语义判断任务，这些单词对要么是一致的，要么是不一致的。
结果
两组中，新的不一致单词对的N400平均波幅相似，但PD组的起始潜伏期延迟。对数据的进一步分析表明，两组在重复的不一致试验中均表现出N400波幅衰减，在重复的一致试验中P600成分也出现衰减。
结论
PD组中存在N400一致性和N400重复效应，这表明语义处理总体上是完整的，但如延迟的N400所示，其时间进程较慢。需要进一步的研究来确定N400和P600重复效应是否对PD患者进一步的认知衰退敏感。（《神经心理学杂志》，2017年，第23卷，第78 - 89页）
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