Weil Merav, Shulman Lester M, Heiman Sophia, Stauber Tali, Alfandari Jacqueline, Weiss Leah, Silberstein Ilana, Indenbaum Viki, Mendelson Ella, Sofer Danit
Central Virology Laboratory, Public Health Services, Israel Ministry of Heath, at Sheba Medical Center, Tel Hashomer, Israel.
These authors contributed equally to this work.
Euro Surveill. 2016 Nov 24;21(47). doi: 10.2807/1560-7917.ES.2016.21.47.30408.
Wild poliovirus type-2 has been eradicated, use of live type-2 vaccine has been terminated globally, and all type-2 polioviruses are under strict laboratory containment protocols. Re-emergence may arise from prolonged asymptomatic excretion of poliovirus by hospitalised primary immune deficient (PID) patients, as described here, through repeated exposure of close contacts to high titres of infected material. At this transition time, PID patients should be screened and hospital containment protocols updated in parallel with laboratory containment.
2型野生脊髓灰质炎病毒已被根除，全球范围内已停止使用2型活疫苗，所有2型脊髓灰质炎病毒都处于严格的实验室控制协议之下。如本文所述，住院的原发性免疫缺陷（PID）患者长期无症状排泄脊髓灰质炎病毒，通过密切接触者反复接触高滴度感染物质，可能会导致病毒重新出现。在这个过渡时期，应筛查PID患者，并与实验室控制同步更新医院控制协议。
