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首例原发性免疫缺陷（PID）患者在消灭野生 2 型脊灰病毒后发生 2 型疫苗衍生脊灰病毒（iVDPV2）持续口咽感染的报告。

First report of a persistent oropharyngeal infection of type 2 vaccine-derived poliovirus (iVDPV2) in a primary immune deficient (PID) patient after eradication of wild type 2 poliovirus.

机构信息

Central Virology Laboratory, Public Health Services, Israel Ministry of Health, at Sheba Medical Center, Tel Hashomer, Israel.

Infectious Disease Unit, Sheba Medical Center, Tel Hashomer, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

出版信息

Int J Infect Dis. 2019 Jun;83:40-43. doi: 10.1016/j.ijid.2019.03.037. Epub 2019 Apr 3.

DOI:10.1016/j.ijid.2019.03.037
PMID:30953828
Abstract

This is the first report of persistent oropharyngeal mucosal infection with type 2 poliovirus (iVDPV2) in a primary immune deficient patient (PID) after wild type 2 poliovirus eradication. The iVDPV2 also established persistence in the gut. iVDPV2 at both loci evolved independently. Persistent oral infections present a potential risk for oral-oral as well as fecal-oral poliovirus transmission during transition to a poliovirus 2-free world.

摘要

这是首例原发性免疫缺陷患者（PID）在野病毒 2 型脊灰（WPV2）根除后发生 2 型脊灰病毒（iVDPV2）持续口咽黏膜感染的报告。该 iVDPV2 也在肠道中持续存在。两个部位的 iVDPV2 均独立进化。在向无脊灰病毒 2 型世界过渡期间，持续的口腔感染可能会增加病毒经口-口及粪-口传播的风险。

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