Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Mult Scler Relat Disord. 2016 Nov;10:179-180. doi: 10.1016/j.msard.2016.09.013. Epub 2016 Sep 30.
Several lines of evidence point towards the importance of genetic risk factors in the susceptibility to multiple sclerosis (MS). We aimed to compare the rates of consanguineous marriages between first cousins among parents of MS patients and a healthy unrelated control group.
This study is a cross-sectional hospital registry based study, which was performed by analyzing the clinical records of patients registered with the Kashani hospital database, and also a control group of randomly selected healthy individuals.
MS patients were significantly less an offspring of a consanguineous union than the control group (MS patients=26.1%, vs Control=32.7%, p=0.03; OR=0.730 95%CI: 0.55-0.97) CONCLUSION: Offspring of consanguineous unions seems to have a lower risk of MS compared to offspring of unrelated parents. This may have implications for inheritance mode of protective alleles in MS.
有几条证据表明遗传风险因素在多发性硬化症（MS）易感性中起着重要作用。我们旨在比较 MS 患者父母与健康无关对照组之间第一代表亲之间近亲结婚的比率。
本研究是一项基于医院的横断面登记研究，通过分析 Kashani 医院数据库中登记的患者的临床记录以及随机选择的健康个体对照组来进行。
与对照组相比，MS 患者的后代近亲结婚的比例明显较低（MS 患者=26.1%，对照组=32.7%，p=0.03；OR=0.730 95%CI：0.55-0.97）。
与无血缘关系的父母相比，近亲结婚的后代患 MS 的风险似乎较低。这可能对 MS 中保护性等位基因的遗传模式有影响。
