Meshalkina Darya A, Kizlyk Marina N, Kysil Elana V, Collier Adam D, Echevarria David J, Abreu Murilo S, Barcellos Leonardo J G, Song Cai, Kalueff Allan V
Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg 199034, Russia.
Department of Psychology, University of Southern Mississippi, Hattiesburg, MS, USA.
Behav Processes. 2017 Aug;141(Pt 2):229-241. doi: 10.1016/j.beproc.2016.11.020. Epub 2016 Dec 2.
Zebrafish (Danio rerio) are rapidly becoming a popular model organism in translational and cognitive neuroscience research. Both larval and adult zebrafish continue to increase our understanding of cognitive mechanisms and their genetic and pharmacological modulation. Here, we discuss the developing utility of zebrafish in understanding cognitive phenotypes and their deficits, relevant to a wide range human brain disorders. We also discuss the potential of zebrafish models for high-throughput genetic mutant and small molecule screening (e.g., amnestics, cognitive enhancers, neurodevelopmental/neurodegenerative drugs), which becomes critical for identifying novel candidate genes and molecular drug targets to treat cognitive deficits. In addition to discussing the existing challenges and future strategic directions in this field, we emphasize how zebrafish models of cognitive phenotypes continue to form an interesting and rapidly emerging new field in neuroscience.
斑马鱼（Danio rerio）正迅速成为转化神经科学和认知神经科学研究中一种受欢迎的模式生物。幼体和成体斑马鱼都在不断增进我们对认知机制及其遗传和药理学调节的理解。在此，我们讨论斑马鱼在理解与多种人类脑部疾病相关的认知表型及其缺陷方面日益增长的效用。我们还讨论了斑马鱼模型用于高通量遗传突变体和小分子筛选（例如，遗忘药、认知增强剂、神经发育/神经退行性药物）的潜力，这对于识别治疗认知缺陷的新候选基因和分子药物靶点至关重要。除了讨论该领域现有的挑战和未来的战略方向外，我们还强调认知表型的斑马鱼模型如何继续在神经科学中形成一个有趣且迅速兴起的新领域。
