新辅助治疗后骨骼肌质量降低与食管癌患者预后不良相关。
Decreased Skeletal Muscle Mass After Neoadjuvant Therapy Correlates with Poor Prognosis in Patients with Esophageal Cancer.
作者信息
Liu Jiajia, Motoyama Satoru, Sato Yusuke, Wakita Akiyuki, Kawakita Yuta, Saito Hajime, Minamiya Yoshihiro
机构信息
Department of General Thoracic Surgery, Akita University Graduate School of Medicine, Akita, Japan
Department of General Thoracic Surgery, Akita University Graduate School of Medicine, Akita, Japan.
出版信息
Anticancer Res. 2016 Dec;36(12):6677-6685. doi: 10.21873/anticanres.11278.
BACKGROUND
Loss of skeletal muscle is predictive of a poor prognosis in patients with various malignant lesions. Our aim was to determine whether changes in skeletal muscle after neo-adjuvant therapy (NAT) predict prognosis in patients with esophageal squamous cell carcinoma (ESCC) undergoing esophagectomy.
PATIENTS AND METHODS
The cross-sectional areas of the psoas muscles were measured on computed tomographic images collected at the initial visit, preoperatively and postoperatively in 84 patients. The psoas muscle index (PMI) was calculated by normalizing the cross-sectional areas to the patients' heights.
RESULTS
Low PMI at the initial visit was not associated with a poor prognosis. The majority of patients showed decreased PMI after NAT and surgery. The group in which the post-NAT PMI decreased had poorer overall survival than group without PMI decrease (p=0.025).
CONCLUSION
Decreased PMI correlates well with a poor prognosis in patients with ESCC. Changes in PMI over a period of time may have greater sensitivity when evaluating prognosis than the PMI at any single time point.
背景
骨骼肌量减少预示着各种恶性病变患者预后不良。我们的目的是确定新辅助治疗（NAT）后骨骼肌的变化是否能预测接受食管切除术的食管鳞状细胞癌（ESCC）患者的预后。
患者与方法
对84例患者初诊时、术前及术后采集的计算机断层扫描图像上的腰大肌横截面积进行测量。腰大肌指数（PMI）通过将横截面积除以患者身高进行标准化计算。
结果
初诊时低PMI与预后不良无关。大多数患者在NAT和手术后PMI降低。NAT后PMI降低的组总体生存率低于PMI未降低的组（p=0.025）。
结论
PMI降低与ESCC患者预后不良密切相关。在评估预后时，一段时间内PMI的变化可能比任何单个时间点的PMI具有更高的敏感性。
Zotero 插件