Department of Gastroenterology, Omagari Kousei Medical Center, Omagari, Japan.
Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
J Med Virol. 2017 Jun;89(6):1116-1120. doi: 10.1002/jmv.24743. Epub 2016 Dec 26.
Full-length genomic sequences of hepatitis E virus (HEV) obtained from two consecutive cases of acute self-limiting hepatitis E in a city in northeast Japan were determined. Interestingly, two HEV isolates from each patient shared nucleotide identity of 99.97% in 7 225 nucleotides, and a phylogenetic analysis showed that they formed a cluster of Japanese isolates that is considered as a new HEV subtype 3k. The high similarity of HEV sequences of two isolates from these patients in this study suggested that a subtype 3k HEV strain had spread via a commonly distributed food in the city, possibly pig liver.
从日本东北部某城市的两例连续急性自限性戊型肝炎患者中获得了戊型肝炎病毒（HEV）全长基因组序列。有趣的是，每位患者的两个 HEV 分离株在 7225 个核苷酸中有 99.97%的核苷酸同一性，系统进化分析表明，它们形成了一个被认为是新的 HEV 3k 亚型的日本分离株群。本研究中来自这两例患者的 HEV 序列高度相似，提示一种 3k 亚型 HEV 株通过城市中一种常见的食物（可能是猪肝）传播。
