染色体分离：重建动粒。

Chromosome Segregation: Reconstituting the Kinetochore.

机构信息

Department of Biochemistry, Stanford Medical School, Stanford, CA, USA.

出版信息

Curr Biol. 2016 Dec 5;26(23):R1242-R1245. doi: 10.1016/j.cub.2016.09.051.

DOI:10.1016/j.cub.2016.09.051

Abstract

Faithful chromosome segregation is accomplished by attachment of chromosomes to spindle microtubules using the kinetochore. In a major step forward in understanding the functional and structural complexity of kinetochores, a 21-subunit human centromere - kinetochore complex has been reconstituted entirely from purified components, recreating the connection between DNA and microtubule.

摘要

染色体的正确分离是通过动粒附着于纺锤体微管来实现的。在深入理解动粒的功能和结构复杂性方面迈出了重要一步，一个由 21 个亚基组成的人类着丝粒-动粒复合物已经从纯组分中完全重建，重新建立了 DNA 和微管之间的连接。