Martyn C N, Singh S, Wood P J
MRC Environmental Epidemiology, Southampton General Hospital, UK.
Gerontology. 1989;35(2-3):153-7. doi: 10.1159/000213014.
Aluminium is present in senile plaques and in neurofibrillary tangle-bearing neurones in brains of cases of Alzheimer's disease. Evidence linking aluminium absorption to calcium metabolism prompted a case-control study of physiological markers of calcium homeostasis in patients with Alzheimer's disease. Mean plasma 25-hydroxyvitamin D concentration was lower in cases than in controls but no difference in median parathyroid hormone concentrations or other evidence of altered calcium metabolism was found. The difference in 25-hydroxyvitamin D concentrations may be secondary to differences in exposure to sunlight.
铝存在于阿尔茨海默病患者大脑的老年斑和含有神经原纤维缠结的神经元中。铝吸收与钙代谢之间的联系证据促使对阿尔茨海默病患者钙稳态生理标志物进行病例对照研究。病例组的平均血浆25-羟维生素D浓度低于对照组，但甲状旁腺激素浓度中位数无差异，也未发现钙代谢改变的其他证据。25-羟维生素D浓度的差异可能继发于阳光照射的差异。
