Trandafir L M, Temneanu O R
Mother and Child Department, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania.
J Med Life. 2016 Oct-Dec;9(4):386-391.
Obesity is considered a condition presenting a complex, multi-factorial etiology that implies genetic and non-genetic factors. The way the available information should be efficiently and strategically used in the obesity and overweight prohylaxisprogrammes for children all over the world is still unclear for most of the risk factors. Mothers' pre-conception weight and weight gain during pregnancy are two of the most important prenatal determinants of childhood obesity. Maternal obesity and gestational weight gain are associated with foetal macrosomia and childhood obesity, and this effect extends into adulthood. Obesity and the metabolic syndrome in children originate in intrauterine life. The current obesity epidemic is probably the result of our evolutive inheritance associated with the consumption of highly processed food with an increased calorific value. The determination of risk factors involved in child obesity are: genetic predisposition, diet, sedentary behaviors, socioeconomic position, ethnic origin, microbiota, iatrogenic, endocrine diseases, congenital and acquired hypothalamic defects, usage of medications affecting appetite. However, the vast majority of patients will not have any of these identifiable conditions. Regardless of the aetiology, all the patients should be considered for modifiable lifestyle risk factors and screened for the complications of obesity.
肥胖被认为是一种病因复杂、多因素的病症,涉及遗传和非遗传因素。对于世界上大多数危险因素而言,如何在儿童肥胖和超重预防计划中有效且策略性地利用现有信息仍不明确。母亲孕前体重和孕期体重增加是儿童肥胖最重要的两个产前决定因素。母亲肥胖和孕期体重增加与胎儿巨大儿和儿童肥胖相关,且这种影响会持续到成年期。儿童肥胖和代谢综合征始于子宫内生活。当前的肥胖流行可能是我们与食用高热量加工食品相关的进化遗传的结果。儿童肥胖所涉及的危险因素包括:遗传易感性、饮食、久坐行为、社会经济地位、种族起源、微生物群、医源性因素、内分泌疾病、先天性和后天性下丘脑缺陷、影响食欲的药物使用。然而,绝大多数患者不会有这些可识别的病症。无论病因如何,所有患者都应考虑可改变的生活方式危险因素,并筛查肥胖并发症。