β-连环蛋白的核表达和/或膜表达降低与结直肠癌的不良预后相关：一项荟萃分析。
Nuclear expression and/or reduced membranous expression of β-catenin correlate with poor prognosis in colorectal carcinoma: A meta-analysis.
作者信息
Zhang Shizhen, Wang Zhen, Shan Jinlan, Yu Xiuyan, Li Ling, Lei Rui, Lin Daozhe, Guan Siqi, Wang Xiaochen
机构信息
Department of Oncology and Cancer Institute (Key Laboratory of Cancer Prevention & Intervention, National Ministry of Education, Provincial Key Laboratory of Molecular Biology in Medical Sciences), Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China Division of Hematopoietic Stem Cell and Leukemia Research, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA Department of Plastic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou Department of surgical oncology, Third Affiliate Hospital of Wenzhou Medical University, Wenzhou Department of Reproductive, Integrated Chinese and Western Medicine Hospital of Zhejiang Province, Hangzhou, China.
出版信息
Medicine (Baltimore). 2016 Dec;95(49):e5546. doi: 10.1097/MD.0000000000005546.
BACKGROUND
The differential subcellular localizations of β-catenin (including membrane, cytoplasm, and nucleus) play different roles in the progression of colorectal cancer (CRC). However, the correlation between each subcellular localization of β-catenin and the prognosis of CRC patients remains undetermined.
METHODS
Systematic strategies were applied to search for eligible published studies in the PubMed, Embase, and Web of Science databases. The correlation between each subcellular localizations of β-catenin expression and patients' clinicopathological features or prognosis was analyzed.
RESULTS
Finally, this meta-analysis, including 6238 cases from 34 studies, revealed that β-catenin overexpression in the nucleus (HR: 1.50[95% CI: 1.08-2.10]) or reduced expression of β-catenin in the membrane (HR: 1.33[95% CI: 1.15-1.54]) significantly correlated with lower 5-year overall survival (OS). Conversely, overexpression of β-catenin in the cytoplasm (HR: 1.00[95% CI: 0.85-1.18]) did not show significant association with 5-year OS.
CONCLUSION
This study suggested that β-catenin overexpression in the nucleus or reduced expression in the membrane, but not its overexpression in cytoplasm, could serve as a valuable prognostic predictor for CRC. However, additional large and well-designed prospective studies are required to verify our results.
背景
β-连环蛋白在不同亚细胞定位（包括细胞膜、细胞质和细胞核）在结直肠癌（CRC）进展中发挥不同作用。然而，β-连环蛋白各亚细胞定位与CRC患者预后之间的相关性仍未确定。
方法
应用系统策略在PubMed、Embase和Web of Science数据库中检索符合条件的已发表研究。分析β-连环蛋白表达的各亚细胞定位与患者临床病理特征或预后之间的相关性。
结果
最终，这项纳入34项研究中6238例病例的荟萃分析显示，细胞核中β-连环蛋白过表达（HR：1.50[95%CI：1.08 - 2.10]）或细胞膜中β-连环蛋白表达降低（HR：1.33[95%CI：1.15 - 1.54]）与5年总生存率（OS）显著相关。相反，细胞质中β-连环蛋白过表达（HR：1.00[95%CI：0.85 - 1.18]）与5年OS无显著关联。
结论
本研究表明，细胞核中β-连环蛋白过表达或细胞膜中表达降低，而非细胞质中过表达，可作为CRC有价值的预后预测指标。然而，需要更多大型且设计良好的前瞻性研究来验证我们的结果。
Zotero 插件