Mulder A F, van Eyck J, Groenendaal F, Wladimiroff J W
Department of Obstetrics and Gynaecology, Academic Hospital Rotterdam, The Netherlands.
Hum Genet. 1989 Oct;83(3):300-1. doi: 10.1007/BF00285179.
We report a very rare case of a pair of monozygotic twins with trisomy 18 discordant for major anomalies. Our case contributes to published data on the role of nongenetic factors in the etiology of discordance of congenital malformations in genotypically identical twins. We stress the importance of accurate ultrasonic examination in reducing the number of caesarean sections to deliver trisomy 18 infants.
我们报告了一对单卵双胞胎的极为罕见的病例，这对双胞胎患有18三体综合征，但主要异常情况不一致。我们的病例为已发表的数据增添了内容，这些数据涉及非遗传因素在基因型相同的双胞胎先天性畸形不一致病因中的作用。我们强调准确的超声检查对于减少为分娩18三体综合征婴儿而进行剖宫产手术数量的重要性。
