萘醌类聚酮化合物从链霉菌属 RI-77 中分离出来及其预测的生物合成途径。
Naphthoquinone-like polyketide isolated from Streptomyces sp. RI-77 and its predicted biosynthetic pathway.
机构信息
Biomedicinal Information Research Center (BIRC), Japan Biological Informatics Consortium (JBIC), 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan.
出版信息
J Nat Prod. 2011 Dec 27;74(12):2588-91. doi: 10.1021/np200651e. Epub 2011 Dec 6.
A novel naphthoquinone-like polyketide, JBIR-85 (1), with a unique skeleton and antioxidative activity was isolated from a culture of Streptomyces sp. RI-77. The planar structure of 1 was established on the basis of extensive NMR and MS analyses. The structure of 1 including the absolute configuration was established via X-ray crystallographic analysis. Since 1 exhibits a unique skeleton, we performed feeding experiments to reconfirm the structure and predict the biosynthetic pathway.
从链霉菌属 RI-77 的培养物中分离得到了一种具有独特骨架和抗氧化活性的新型萘醌类聚酮化合物 JBIR-85（1）。通过广泛的 NMR 和 MS 分析确定了 1 的平面结构。通过 X 射线晶体学分析确定了 1 的结构（包括绝对构型）。由于 1 具有独特的骨架，我们进行了喂食实验以重新确认结构并预测生物合成途径。
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