Sun Shi-Wei, Ji Chang-Zhu, Gu Qian-Qun, Li De-Hai, Zhu Tian-Jiao
a Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao , 266003 , China.
J Asian Nat Prod Res. 2013 Sep;15(9):956-61. doi: 10.1080/10286020.2013.826205. Epub 2013 Aug 15.
Two new benzyl derivatives, aspergentisyl A (1) and aspergentisyl B (2), as well as one new naphthoquinone derivative, aspergiodiquinone (3), together with seven known prenylated benzaldehyde derivatives (4-10) were isolated from the marine-derived fungus Aspergillus glaucus HB1-19. The structures of these compounds were characterized based on 1D and 2D NMR spectra analyses and comparison with those reported in the literature. In addition, each isolate was tested for its 1,1-diphenyl-2-picrylhydrazyl radical-scavenging property and all these compounds except compound 3 exhibited strong radical-scavenging activity.
从海洋来源的真菌灰绿曲霉HB1-19中分离出两种新的苄基衍生物，曲霉苄基甲醚A（1）和曲霉苄基甲醚B（2），以及一种新的萘醌衍生物，曲霉二醌（3），还有七种已知的异戊烯基化苯甲醛衍生物（4-10）。这些化合物的结构通过一维和二维核磁共振光谱分析并与文献报道的结构进行比较得以表征。此外，对每种分离物进行了1,1-二苯基-2-苦基肼自由基清除性能测试，除化合物3外，所有这些化合物均表现出较强的自由基清除活性。
