Cordeiro Cynthia Azeredo, Vieira Erica Leandro Marciano, Rocha Natália Pessoa, Castro Vinicius Monteiro, Oréfice Juliana Lambert, Barichello Tatiana, Costa Rogerio Alves, Oréfice Fernando, Young Lucy, Teixeira Antonio Lucio
Universidade Federal de Minas Gerais, Faculdade de Medicina, Laboratório Interdisciplinar de Investigação Médica, Belo Horizonte, MG, Brazil; Centro Brasileiro de Ciências Visuais, Belo Horizonte, MG, Brazil; Massachusetts Eye and Ear Infirmary, Retina Department, Boston, United States.
Universidade Federal de Minas Gerais, Faculdade de Medicina, Laboratório Interdisciplinar de Investigação Médica, Belo Horizonte, MG, Brazil.
Braz J Infect Dis. 2017 Mar-Apr;21(2):176-179. doi: 10.1016/j.bjid.2016.11.005. Epub 2016 Dec 5.
Toxoplasmic retinochoroiditis (TR) is the most common identifiable cause of posterior uveitis in Brazil. Response to treatment and clinical presentation may vary significantly. We assessed serum levels of brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), neurotrophin (NT)-3, and NT-4/5 in patients with active TR, before and after TR treatment.
Twenty patients with active lesion and 15 healthy controls were enrolled in the study. Serum concentration of neurotrophic factors was determined by enzyme-linked immunosorbent assay.
BDNF levels were significantly higher in patients before treatment when compared with controls (p=0.0015). There was no significant difference in pro-BDNF, NGF, GDNF, NT-3, and NT-4/5 levels between TR patients and controls. Treatment did not affect the levels of these factors.
BDNF may be released in the context of the active TR inflammatory response.
弓形虫性视网膜脉络膜炎（TR）是巴西后部葡萄膜炎最常见的可识别病因。对治疗的反应和临床表现可能有显著差异。我们评估了活动性TR患者在TR治疗前后血清中脑源性神经营养因子（BDNF）、胶质细胞系源性神经营养因子（GDNF）、神经生长因子（NGF）、神经营养素（NT）-3和NT-4/5的水平。
本研究纳入了20例有活动性病变的患者和15名健康对照。通过酶联免疫吸附测定法测定神经营养因子的血清浓度。
与对照组相比，治疗前患者的BDNF水平显著更高（p = 0.0015）。TR患者与对照组之间的前体BDNF、NGF、GDNF、NT-3和NT-4/5水平无显著差异。治疗未影响这些因子的水平。
BDNF可能在活动性TR炎症反应的情况下释放。
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