二甲双胍相关性乳酸酸中毒

Metformin associated lactic acidosis.

作者信息

Phillips P J, Scicchitano R, Clarkson A R, Gilmore H R

出版信息

Aust N Z J Med. 1978 Jun;8(3):281-4. doi: 10.1111/j.1445-5994.1978.tb04524.x.

DOI:10.1111/j.1445-5994.1978.tb04524.x

Abstract

A case of lactic acidosis occurring in association with inappropriate and excessive metformin therapy and a high serum metformin concentration is described. In the other 23 cases of metformin associated lactic acidosis reported to December 1977, renal, cardiovascular and liver disease were common. Although metformin is less likely to cause lactic acidosis than phenformin, neither drug should be prescribed in the presence of renal, hepatic or cardiovascular disease.

摘要

本文描述了一例因二甲双胍治疗不当且过量以及血清二甲双胍浓度过高而发生乳酸性酸中毒的病例。在截至1977年12月报告的另外23例二甲双胍相关性乳酸性酸中毒病例中，肾脏、心血管和肝脏疾病较为常见。虽然二甲双胍比苯乙双胍引起乳酸性酸中毒的可能性较小，但在存在肾脏、肝脏或心血管疾病时，这两种药物均不应使用。