Laboratory of Organic Synthesis, Bio and Organocatalysis, Chemistry Department, Universidad de los Andes , Cra 1 No. 18A-12 Q:305, Bogotá 111711, Colombia.
J Org Chem. 2016 Dec 2;81(23):11548-11555. doi: 10.1021/acs.joc.6b02358. Epub 2016 Nov 15.
Amides are unquestionably one of the most important functional groups in organic chemistry because of their presence in numerous interesting molecules such as peptides, pharmaceutical agents, naturally occurring molecules, proteins and alkaloids, among others. This synopsis surveys the diverse recent approaches to amide synthesis from nonactivated carboxylic acids and derivatives as well as noncarboxylic compounds, highlighting the most innovative methodologies and those that are more eco-friendly compared to traditional methods while focusing on recent developments during the past two years.
酰胺无疑是有机化学中最重要的官能团之一，因为它们存在于许多有趣的分子中，如肽、药物制剂、天然分子、蛋白质和生物碱等。这篇综述调查了最近从非活化羧酸和衍生物以及非羧酸化合物合成酰胺的各种方法，重点介绍了与传统方法相比最具创新性和更环保的方法，同时关注了过去两年的最新发展。
