Instituto de Química (INQUI), Universidade Federal de Mato Grosso do Sul, 79074-460, Campo Grande, Mato Grosso do Sul, Brazil.
Crop Protection Chemicals Division, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad, 500007, India.
Chem Asian J. 2019 Feb 1;14(3):344-388. doi: 10.1002/asia.201801560. Epub 2019 Jan 9.
The formation of amide bonds is one of the most stimulating emerging areas in organic and medicinal chemistry. Amides are recognized as central building blocks in a plethora of interesting pharmaceuticals, proteins, peptides, polymers, natural products, functional materials, and biologically relevant carbocyclic or heterocyclic molecules, and they are also found in a variety of industrial fields. Therefore, a review of recent developments and challenges in the formation of amide bonds from carbonyl compounds is particularly important. Herein, we have scrutinized a range of metal-catalyzed and metal-free approaches for the synthesis of amides from aldehydes, ketones, and oximes. In addition, this Minireview highlights relevant mechanistic studies, as well as the potential applications of these methods in the synthesis of candidate drug molecules. We hope that the data compiled herein will encourage further progress in this notable area of chemistry research.
酰胺键的形成是有机和药物化学中最具活力的新兴领域之一。酰胺被认为是许多有趣的药物、蛋白质、肽、聚合物、天然产物、功能材料以及与生物相关的碳环或杂环分子的核心构建块，它们也存在于各种工业领域中。因此，综述羰基化合物形成酰胺键的最新发展和挑战尤为重要。在此，我们仔细研究了一系列用于从醛、酮和肟合成酰胺的金属催化和无金属方法。此外，本综述还强调了相关的机理研究，以及这些方法在候选药物分子合成中的潜在应用。我们希望本文中汇编的数据将鼓励这一重要化学研究领域的进一步发展。
