Benachinmardi K K, Rajalakshmi P, Veenakumari H B, Bharath R D, Vikas V, Mahadevan A, Nagarathna S
Department of Neuromicrobiology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Indian J Med Microbiol. 2016 Oct-Dec;34(4):550-553. doi: 10.4103/0255-0857.195373.
Fungal brain abscess is rare with a rapidly progressive disease with fulminant course and invariably fatal outcome, unless diagnosed early and treated rapidly. We report a 56-year-old woman diagnosed to have fungal abscess who recovered completely following amphotericin B treatment. She presented with weakness of the right hand, deviation of mouth to left and aphasia for 2 days. Computed tomography of the brain revealed a left frontal capsuloganglionic hypodense lesion. Stereotactic biopsy was performed, and microbiological confirmation of non-septate fungal hyphae from pus from aspirate within 2 h helped initiate timely and appropriate treatment leading to cure. Histopathology and culture later confirmed mucormycosis.
真菌性脑脓肿较为罕见，是一种病情迅速进展、病程凶险且预后往往致命的疾病，除非早期诊断并迅速治疗。我们报告了一名56岁被诊断为真菌性脓肿的女性，经两性霉素B治疗后完全康复。她因右手无力、口角向左偏斜及失语2天就诊。脑部计算机断层扫描显示左侧额叶豆状核囊状低密度病变。进行了立体定向活检，在2小时内从吸出的脓液中微生物学确认存在非分隔真菌菌丝，这有助于及时开始适当治疗并实现治愈。组织病理学和培养后来证实为毛霉菌病。
