Giudice Giuseppe, Cutrignelli Daniela Anna, Sportelli Pasquale, Limongelli Luisa, Tempesta Angela, Gioia Giuseppe Di, Santacroce Luigi, Maiorano Eugenio, Favia Gianfranco
Ionian Department, Microbiology and Virology Lab. "Policlinico" University Hospital, P.zza G. Cesare, 11, 70124 Bari, Italy.
Endocr Metab Immune Disord Drug Targets. 2016;16(4):264-269. doi: 10.2174/1871530316666161223145055.
Rhinocerebral mucormycosis is a rare, rapidly progressive and potentially lethal disease almost exclusively affecting immunocompromised hosts or patients with metabolic disorders, such as poorly controlled diabetes mellitus.
This work is aimed to describe five cases of rhinocerebral mucormycosis to review and possibly define diagnostic and surgical treatment guidelines. In all the patients, surgical debridement, systemic and local antifungal therapy, and oral rehabilitation using filling prostheses were performed.
None of the patients revealed recurrence of the infection, as confirmed by radiological and clinical long term follow up.
Given the lethal nature of the disease, the authors underline the importance of early diagnosis and of a multidisciplinary approach in order to undertake correct surgical and medical treatments, while keeping the underlying disease under control.
鼻脑型毛霉菌病是一种罕见的、进展迅速且可能致命的疾病，几乎仅影响免疫功能低下的宿主或患有代谢紊乱（如控制不佳的糖尿病）的患者。
这项工作旨在描述5例鼻脑型毛霉菌病病例，以回顾并可能确定诊断和外科治疗指南。对所有患者均进行了手术清创、全身和局部抗真菌治疗以及使用填充假体进行口腔修复。
经影像学和临床长期随访证实，所有患者均未出现感染复发。
鉴于该疾病的致命性，作者强调早期诊断和多学科方法的重要性，以便进行正确的手术和药物治疗，同时控制基础疾病。
