Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, College of Animal Science, Zhejiang University, Hangzhou, China.
Food Funct. 2021 May 21;12(10):4246-4253. doi: 10.1039/d0fo03442h. Epub 2021 Apr 20.
Iron plays a vital role in the metabolism of adipose tissue. On the one hand, iron is essential for differentiation, endocrine, energy supply and other physiological functions of adipocytes. Iron homeostasis affects the progression of many chronic metabolic diseases such as obesity, type 2 diabetes mellitus, and non-alcoholic fatty liver disease. In adipose tissue, iron deficiency is associated with obesity, mainly due to inflammation. Nevertheless, excessive iron in adipose tissue leads to decreased insulin sensitivity owing to mitochondrial dysfunction and adipokine changes. On the other hand, iron has an effect on the thermogenesis of adipocytes. Iron deficiency affects the production of beige fat and the direction of the differentiation of brown fat. In this review, we summarize the current understanding of the crosstalk between iron homeostasis and metabolism in adipose tissue.
铁在脂肪组织代谢中起着至关重要的作用。一方面，铁是脂肪细胞分化、内分泌、能量供应和其他生理功能所必需的。铁稳态影响许多慢性代谢疾病的进展，如肥胖、2 型糖尿病和非酒精性脂肪肝疾病。在脂肪组织中，铁缺乏与肥胖有关，主要是由于炎症。然而，脂肪组织中铁过多会导致线粒体功能障碍和脂肪细胞因子变化，从而降低胰岛素敏感性。另一方面，铁对脂肪细胞的产热有影响。铁缺乏会影响米色脂肪的产生和棕色脂肪分化的方向。在这篇综述中，我们总结了目前对铁稳态与脂肪组织代谢之间相互作用的理解。
