Funayama S, Anraku Y, Mita A, Komiyama K, Omura S
Kitasato Institute, Tokyo, Japan.
J Antibiot (Tokyo). 1989 Sep;42(9):1350-5. doi: 10.7164/antibiotics.42.1350.
Structures of three antioxidant isoflavonoids isolated from the cultured broth of Streptomyces sp. OH-1049 were shown to be 4',7,8-trihydroxyisoflavone (1), 3',4',7-trihydroxyisoflavone (2) and 8-chloro-3',4',5,7-tetrahydroxyisoflavone (3), respectively. Among them, 3 is a novel isoflavonoid possessing a chlorine atom in the molecule. Compound 1 was synthesized and its antitumor activities were tested against IMC carcinoma, S180, P388 leukemia and P388/ADM leukemia in vivo. As a result, 1 showed 139% increase in life span (ILS) against S180 bearing mice whereas it showed slight or no ILS against IMC carcinoma, P388 leukemia and P388/ADM leukemia bearing mice.
从链霉菌属菌株OH - 1049的培养液中分离出的三种抗氧化异黄酮类化合物的结构分别被证明为4',7,8 - 三羟基异黄酮（1）、3',4',7 - 三羟基异黄酮（2）和8 - 氯 - 3',4',5,7 - 四羟基异黄酮（3）。其中，化合物3是一种分子中含有氯原子的新型异黄酮类化合物。合成了化合物1，并在体内针对IMC癌、S180、P388白血病和P388/ADM白血病测试了其抗肿瘤活性。结果表明，化合物1对荷S180小鼠的寿命延长率（ILS）为139%，而对荷IMC癌、P388白血病和P388/ADM白血病小鼠的ILS轻微或无明显延长。
