原癌菌素，一种新型抗肿瘤抗生素。

Prothracarcin, a novel antitumor antibiotic.

作者信息

Shimizu K, Kawamoto I, Tomita F, Morimoto M, Fujimoto K

出版信息

J Antibiot (Tokyo). 1982 Aug;35(8):972-8. doi: 10.7164/antibiotics.35.972.

DOI:10.7164/antibiotics.35.972

PMID:7142014

Abstract

A novel antibiotic, prothracarcin was isolated from the culture broth of Streptomyces umbrosus subsp. raffinophilus DO-62. The antibiotic has the molecular formula of C14H14N2O and belongs to the pyrrolo [1,4]benzodiazepine antibiotics. Its structure has been elucidated by mass and NMR spectra. It is active against Gram-positive and Gram-negative bacteria and experimental murine tumor sarcoma 180 and leukemia P388.

摘要

一种新型抗生素——原蒽环素，是从暗产色链霉菌嗜棉子糖亚种DO - 62的培养液中分离得到的。该抗生素的分子式为C14H14N2O，属于吡咯并[1,4]苯并二氮杂卓类抗生素。其结构已通过质谱和核磁共振光谱得以阐明。它对革兰氏阳性菌和革兰氏阴性菌以及实验性小鼠肿瘤肉瘤180和白血病P388具有活性。