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胎儿生长受限的综合治疗方法。

An integrated approach to fetal growth restriction.

作者信息

Figueras Francesc, Gratacos Eduard

机构信息

Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona, Spain; Centre for Biomedical Research on Rare Diseases (CIBER-ER), Spain.

Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona, Spain; Centre for Biomedical Research on Rare Diseases (CIBER-ER), Spain.

出版信息

Best Pract Res Clin Obstet Gynaecol. 2017 Jan;38:48-58. doi: 10.1016/j.bpobgyn.2016.10.006. Epub 2016 Oct 20.

Abstract

Fetal growth restriction (FGR) is among the most common complications of pregnancy. FGR is associated with placental insufficiency and poor perinatal outcomes. Clinical management is challenging because of variability in clinical presentation. Fetal smallness (estimated fetal weight <10th centile for gestational age) remains the best clinical surrogate for FGR. However, it is commonly accepted that not all forms of fetal smallness represent true FGR. In a significant subset of small fetuses, there is no evidence of placental involvement, perinatal outcomes are nearly normal, and they are clinically referred to as "only" small for gestational age (SGA). Doppler may improve the clinical management of FGR; however, the need to use several parameters sometimes results in a number of combinations that may render interpretation challenging when translating into clinical decisions. We propose that the management of FGR can be simplified using a sequential approach based on three steps: (1) identification of the "small fetus," (2) differentiation between FGR and SGA, and (3) timing of delivery according to a protocol based on stages of fetal deterioration.

摘要

胎儿生长受限(FGR)是妊娠期最常见的并发症之一。FGR与胎盘功能不全及不良围产期结局相关。由于临床表现存在差异,临床管理具有挑战性。胎儿偏小(估计胎儿体重低于孕周的第10百分位数)仍是FGR最佳的临床替代指标。然而,人们普遍认为并非所有形式的胎儿偏小都代表真正的FGR。在相当一部分偏小胎儿中,没有胎盘受累的证据,围产期结局近乎正常,临床上将其称为“仅”小于孕周(SGA)。多普勒检查可能会改善FGR的临床管理;然而,由于需要使用多个参数,有时会产生多种组合,这在转化为临床决策时可能会使解读具有挑战性。我们建议可采用基于三个步骤的序贯方法简化FGR的管理:(1)识别“偏小胎儿”,(2)区分FGR和SGA,(3)根据基于胎儿恶化阶段的方案确定分娩时机。

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