Jagani Mamta, Legay Hélène, Ranmal Sejal R, Bertrand Julie, Ooi Kuan, Tuleu Catherine
Great Ormond Street Hospital for Children National Health Service Foundation Trust, London, United Kingdom.
School of Pharmacy, and.
Pediatrics. 2016 Dec;138(6). doi: 10.1542/peds.2016-0680. Epub 2016 Nov 1.
Pediatric pharmacists are constantly faced with the challenges of supporting children and caregivers for whom the difficulties of swallowing medicines can be a daily struggle. Most medicines are only available as tablets and capsules, and where liquid alternatives exist, these products often have issues with palatability and high costs. The objective of this study was to evaluate whether the swallowing spray, Pill Glide, could help children in taking their solid and liquid medicines. This open label pilot study compared the spray with a behavioral approach alone, the current standard of care at the pediatric hospital. Patients were children on long-term drug therapies, either transitioning from liquid preparations to tablets and capsules, or known to be experiencing swallowing difficulties. Using age-adapted diaries, patients self-reported the difficulty of taking medicines on a 6-point hedonic scale for 2 weeks before the intervention, and then for 1 week while using Pill Glide. Data were analyzed from 10 children aged 6 to 16 years, with an average burden of 3.5 tablets per day. Pill Glide (strawberry was the most popular flavor) was shown to significantly decrease the overall medicine taking difficulty score by 0.93 (range, 0.33-1.53), almost 1 hedonic face point on the scale used (P = .002). There was insufficient data for liquid medicines. Pill Glide could help children with pill swallowing, thus improving patient acceptability of medicines and potentially adherence. It could also be implemented as a useful cost-saving intervention because solid dosage forms are cheaper.
儿科药剂师一直面临着为儿童和护理人员提供支持的挑战，对他们来说，吞咽药物的困难可能是日常的难题。大多数药物仅以片剂和胶囊形式提供，而在有液体替代剂型的情况下，这些产品往往存在口感和成本高的问题。本研究的目的是评估吞咽喷雾Pill Glide是否能帮助儿童服用固体和液体药物。这项开放标签的试点研究将该喷雾与单独的行为方法（儿科医院目前的护理标准）进行了比较。患者为接受长期药物治疗的儿童，要么是从液体制剂过渡到片剂和胶囊，要么已知存在吞咽困难。使用适合年龄的日记，患者在干预前2周以6分享乐量表自我报告服药困难程度，然后在使用Pill Glide的1周内进行报告。对10名6至16岁的儿童进行了数据分析，平均每天服药负担为3.5片。结果显示，Pill Glide（草莓味最受欢迎）使总体服药困难评分显著降低了0.93（范围为0.33 - 1.53），在所使用的量表上几乎降低了1个享乐面评分（P = .002）。关于液体药物的数据不足。Pill Glide可以帮助儿童吞咽药丸，从而提高患者对药物的接受度并可能改善依从性。由于固体剂型更便宜，它还可以作为一种有用的成本节约干预措施来实施。
