Harrison M R, Clifton G D, Sublett K L, DeMaria A N
Division of Cardiology, College of Medicine, University of Kentucky, Lexington.
J Am Coll Cardiol. 1989 Oct;14(4):929-35. doi: 10.1016/0735-1097(89)90468-3.
Recent investigations have shown Doppler echocardiography to be useful in the noninvasive assessment of left ventricular systolic function. No data exist, however, regarding the influence of heart rate on Doppler measurements of aortic blood flow velocity and acceleration in humans. Thus, 12 normal volunteers underwent continuous wave Doppler ultrasound recording from the suprasternal notch at baseline and during progressive transesophageal atrial pacing at intervals of 10 beats/min between 90 and 140 beats/min while 100% atrial capture and 1:1 atrioventricular conduction were maintained. Subjects were studied both upright (n = 12) and supine (n = 10). With the subject upright at baseline (mean heart rate 77.8 +/- 10.6 beats/min), peak acceleration averaged to 16.8 +/- 3.4 m/s2, and peak modal velocity and flow velocity integral averaged 0.72 +/- 0.14 m/s and 8.4 +/- 2.1 cm, respectively. With pacing at 90 beats/min, peak acceleration decreased to 15.6 +/- 3.6 m/s2, a significant decline from baseline values (p less than 0.005). Similar declines were seen during pacing at 90 beats/min for peak modal velocity and flow velocity integral (0.64 +/- 0.16 m/s and 7.1 +/- 1.9 cm, respectively; both p less than 0.005 versus baseline values). At the peak pacing rate of 140 beats/min, average peak acceleration decreased to 12.8 +/- 3.1 m/s2, and peak modal velocity and flow velocity integral decreased to 0.52 +/- 0.11 m/s and 5.02 +/- 1.25 cm, respectively. A significant linear correlation (r greater than or equal to 0.97, p less than 0.0001) was obtained for the relation between heart rate and peak acceleration, peak modal velocity and flow velocity integral.(ABSTRACT TRUNCATED AT 250 WORDS)
近期研究表明，多普勒超声心动图在左心室收缩功能的无创评估中很有用。然而，关于心率对人体主动脉血流速度和加速度的多普勒测量值的影响，目前尚无相关数据。因此，12名正常志愿者在基线状态下以及在经食管心房递增起搏过程中，从胸骨上切迹进行连续波多普勒超声记录，起搏频率从90次/分钟至140次/分钟，间隔为10次/分钟，同时维持100%心房夺获和1:1房室传导。对受试者分别进行直立位（n = 12）和仰卧位（n = 10）研究。在基线状态下受试者直立时（平均心率77.8±10.6次/分钟），峰值加速度平均为16.8±3.4米/秒²，峰值众数速度和流速积分分别平均为0.72±0.14米/秒和8.4±2.1厘米。当起搏频率为90次/分钟时，峰值加速度降至15.6±3.6米/秒²，与基线值相比有显著下降（p<0.005）。在起搏频率为90次/分钟时，峰值众数速度和流速积分也出现类似下降（分别为0.64±0.16米/秒和7.1±1.9厘米；与基线值相比，p均<0.005）。在起搏频率峰值140次/分钟时，平均峰值加速度降至12.8±3.1米/秒²，峰值众数速度和流速积分分别降至0.52±0.11米/秒和5.02±1.25厘米。心率与峰值加速度、峰值众数速度和流速积分之间的关系呈现显著的线性相关性（r≥0.97，p<0.0001）。（摘要截选至250字）
