Pang Bingyao, Zhu Ying, Lu Longqing, Gu Fangbing, Chen Hailong
Department of Infectious Diseases, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Evid Based Complement Alternat Med. 2016;2016:3837270. doi: 10.1155/2016/3837270. Epub 2016 Nov 10.
With increasingly improved separation of complex samples and detection of unknown material capabilities, liquid chromatography coupled with mass spectrometry (LC-MS) has been widely used in traditional Chinese medicine (TCM) research. This article describes the principles of liquid chromatography (LC) and mass spectrometry (MS) and their advantages and disadvantages in qualitative and quantitative analysis of TCM. We retrieved research literatures about the application of LC-MS in TCM published during the past five years at home and abroad. To better guide the analysis of TCM, this review mainly focuses on the applications category of LC-MS, how often different kinds of LC-MS are used, and the qualitative and quantitative ability of various LC-MS in the study of TCM.
随着复杂样品分离和未知物质检测能力的日益提高,液相色谱-质谱联用(LC-MS)已在中药研究中得到广泛应用。本文介绍了液相色谱(LC)和质谱(MS)的原理及其在中药定性和定量分析中的优缺点。我们检索了国内外过去五年发表的关于LC-MS在中药中应用的研究文献。为了更好地指导中药分析,本综述主要关注LC-MS的应用类别、不同类型LC-MS的使用频率以及各种LC-MS在中药研究中的定性和定量能力。