在丹麦人群中，13价肺炎球菌结合疫苗（PCV-13）接种并未降低侵袭性肺炎球菌3型疾病的发病率。
The incidence of invasive pneumococcal serotype 3 disease in the Danish population is not reduced by PCV-13 vaccination.
作者信息
Slotved Hans-Christian, Dalby Tine, Harboe Zitta Barrella, Valentiner-Branth Palle, Casadevante Victoria Fernandez de, Espenhain Laura, Fuursted Kurt, Konradsen Helle Bossen
机构信息
Neisseria and Streptococcus Reference Laboratory, Department of Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark.
Neisseria and Streptococcus Reference Laboratory, Department of Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark; Department of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
出版信息
Heliyon. 2016 Nov 29;2(11):e00198. doi: 10.1016/j.heliyon.2016.e00198. eCollection 2016 Nov.
Since 2010, Denmark has included the 13-valent pneumococcal conjugated vaccine (PCV-13) in the childhood immunization programme. However, serotype 3 remains as an important cause of invasive pneumococcal disease (IPD) in Denmark. IPD surveillance data (1999-2016) was used to calculate the incidence and age-distribution of serotype 3 IPD, and the effect of PCV-13 on serotype 3 IPD incidence was examined. The incidence of serotype 3 IPD in the age group below 65 years was 0.51/100,000 pre PCV-13, and 0.45/100,000 post PCV-13. In the group 0-4 years, serotype 3 IPD incidence was 0.28/100,000 pre PCV-13, and 0.16/100,000 post PCV-13. Serotype 3 IPD incidence in the elderly showed a mean of 4.27/100,000 pre PCV-13, and 4.32/100,000 post PCV-13. PCV-13 childhood immunization in Denmark has not lead to a reduction of the incidence of IPD caused by serotype 3. The reason behind this missing effect needs to be investigated further.
自2010年以来，丹麦已将13价肺炎球菌结合疫苗（PCV-13）纳入儿童免疫规划。然而，在丹麦，3型血清型仍然是侵袭性肺炎球菌疾病（IPD）的一个重要病因。利用IPD监测数据（1999 - 2016年）计算3型血清型IPD的发病率和年龄分布，并研究PCV-13对3型血清型IPD发病率的影响。在65岁以下年龄组中，接种PCV-13前3型血清型IPD的发病率为0.51/10万，接种后为0.45/10万。在0 - 4岁组中，接种PCV-13前3型血清型IPD的发病率为0.28/10万，接种后为0.16/10万。老年人中3型血清型IPD的发病率在接种PCV-13前平均为4.27/10万，接种后为4.32/10万。丹麦的儿童PCV-13免疫接种并未导致3型血清型引起的IPD发病率降低。这种缺失效应背后的原因需要进一步调查。
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