英国在接种13价肺炎球菌结合疫苗（PCV13）前（2006 - 2010年）、PCV13早期（2010 - 2012年）和PCV13后期（2012 - 2023年）期间，肺炎链球菌及其他呼吸道共生致病体的携带情况和血清型多样性变化。
Changes in carriage and serotype diversity of Streptococcus pneumoniae and other respiratory pathobionts in the UK between pre-PCV13 (2006-10), early-PCV13 (2010-12) and late-PCV13 (2012-23) periods.
作者信息
Cleary David W, Anderson Rebecca, Jones Jessica, Gladstone Rebecca A, Osman Karen L, Devine Vanessa T, Morris Denise E, Lister Alex J J, Gomer Stephen, Hocknell Rebecca E, Dineen Emily J, Jefferies Johanna M, Campling James, Lahuerta Maria, Hayford Kyla, Southern Jo, Gessner Bradford D, Lo Stephanie W, Bentley Stephen D, Faust Saul N, Clarke Stuart C
机构信息
Department of Microbes, Infection and Microbiomes, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK.
出版信息
Pneumonia (Nathan). 2025 Sep 5;17(1):20. doi: 10.1186/s41479-025-00174-y.
BACKGROUND
The ongoing burden of mortality and morbidity associated with infections requires that monitoring of carriage epidemiology continues. Here, we present data from the annual, cross-sectional surveillance study in Southampton UK on serotype epidemiology and diversity, as well as carriage of other frequent colonisers of the respiratory tract in over 7000 children over a period of seventeen years (2006–2023).
METHODS
Children were recruited from two sites: Site 1 - Southampton General Hospital, administered by University Hospital Southampton (UHS) NHS Foundation Trust and Site 2– a collection of community health care facilities within the Solent NHS Trust region. Recruitment was limited to children < 5-years-old. Pneumococcal serotyping was done using whole genome sequence data.
RESULTS
A total of 7,686 swabs were collected from which 2,386 (31%) pneumococci were recovered. Carriage of pneumococci has remained consistent (median carriage prevalence 31.4%) even with the almost complete removal of vaccine-type (VT) serotypes. Examining three PCV13 periods separately (pre, early and late), carriage was not significantly different at 27.7%, 35.3% and 39.3% respectively. A decrease in carriage of , and was seen pre-PCV13 (following PCV7 implementation) but has since stabilised. Continued, low-level persistence of VTs 3, 19A and 19F was noted. PCV13 did not impact the pneumococcal serotype rank abundance despite clear reductions in targeted serotypes and fluctuations in other non-VT serotypes such as 15A, 23B and 23B1. Non-PCV13 PCV20 serotypes 10A and 11A, in addition to paired prevalence of 15B and 15C (15B/C) were in the five most isolated serotypes in the late-PCV13 period (2012 to present). Non-PCV13 PCV20 serotypes now account for approximately 40% of all carriage. By contrast, the serotypes only included in PCV15 (22F and 33F) represented just 7% in the same period.
CONCLUSION
With consistent carriage prevalence in this UK paediatric population since PCV13 introduction, serotype epidemiology is now dominated by non-PCV13 serotypes that are in higher valency vaccines.
SUPPLEMENTARY INFORMATION
The online version contains supplementary material available at 10.1186/s41479-025-00174-y.
背景
感染相关的持续死亡和发病负担要求持续监测携带情况的流行病学。在此，我们展示了英国南安普敦一项为期十七年（2006 - 2023年）的年度横断面监测研究的数据，该研究涉及7000多名儿童的血清型流行病学和多样性，以及呼吸道其他常见定植菌的携带情况。
方法
从两个地点招募儿童：地点1 - 由南安普敦大学医院国民保健服务基金会信托管理的南安普敦总医院，地点2 - 索伦特国民保健服务信托地区内的一系列社区医疗保健机构。招募限于5岁以下儿童。使用全基因组序列数据进行肺炎球菌血清分型。
结果
共收集了7686份拭子，从中分离出2386株（31%）肺炎球菌。即使几乎完全清除了疫苗型（VT）血清型，肺炎球菌的携带率仍保持稳定（中位携带率31.4%）。分别检查三个PCV13时期（之前、早期和晚期），携带率分别为27.7%、35.3%和39.3%，无显著差异。在PCV13之前（PCV7实施后）， 、 和 的携带率有所下降，但此后趋于稳定。注意到VT3、19A和19F持续存在且水平较低。尽管目标血清型明显减少，其他非VT血清型如15A、23B和23B1出现波动，但PCV13并未影响肺炎球菌血清型的优势排名。非PCV13的PCV20血清型10A和11A，以及15B和15C（15B/C）的配对流行率，在PCV13后期（2012年至今）是最常分离出的五种血清型之一。非PCV13的PCV20血清型现在约占所有携带情况的40%。相比之下，仅包含在PCV15中的血清型（22F和33F）在同一时期仅占7%。
结论
自引入PCV13以来，该英国儿科人群的携带率保持稳定，血清型流行病学现在由更高价疫苗中的非PCV13血清型主导。
补充信息
Zotero 插件