Fearnot N E, Kitoh O, Fujita T, Okamura H, Smith H J, Calderini M
Hillenbrand Biomedical Engineering Center, Purdue University, West Lafayette, IN 47907.
Jpn Heart J. 1989 May;30(3):353-63. doi: 10.1536/ihj.30.353.
The effectiveness of using blood temperature change as an indicator to automatically vary heart rate physiologically was evaluated in 3 patients implanted with Model Sensor Kelvin 500 (Cook Pacemaker Corporation, Leechburg, PA, USA) pacemakers. Each patient performed two block-randomized treadmill exercise tests: one while programmed for temperature-based, rate-modulated pacing and the other while programmed without rate modulation. In 1 pacemaker patient and 4 volunteers, heart rates were recorded during exposure to a hot water bath. Blood temperature measured at 10 sec intervals and pacing rate measured at 1 min intervals were telemetered to a diagnostic programmer and data collector for storage and transfer to a computer. Observation comments and ECG-derived heart rates were manually recorded. The temperature-based pacemaker was shown to respond promptly not only to physical exertion but also to emotionally caused stress and submersion in a hot bath. These events cause increased heart rate in the normal heart. Using a suitable algorithm to process the measurement of blood temperature, it was possible to produce appropriate pacing rates in paced patients.
在3名植入了型号为Sensor Kelvin 500（美国宾夕法尼亚州利奇堡市库克起搏器公司）起搏器的患者中，评估了将血液温度变化作为指标来自动生理性改变心率的有效性。每位患者进行了两次分组随机化的跑步机运动测试：一次是在设置为基于温度的频率适应性起搏时进行，另一次是在未设置频率调节时进行。在1名起搏器患者和4名志愿者中，记录了他们在热水浴期间的心率。每隔10秒测量一次的血液温度和每隔1分钟测量一次的起搏频率被遥测到诊断编程器和数据采集器中，以便存储并传输到计算机。观察结果和通过心电图得出的心率由人工记录。结果表明，基于温度的起搏器不仅能对体力活动迅速做出反应，还能对情绪引起的压力以及热水浴浸没做出反应。这些情况会使正常心脏的心率增加。通过使用合适的算法来处理血液温度测量值，有可能为使用起搏器的患者产生适当的起搏频率。
