Yamamoto T, Yamashita H
Department of Ophthalmology, Tokyo Kosei Nenkin Hospital, Japan.
Jpn J Ophthalmol. 1989;33(3):327-36.
The electron microscopic observation of Bruch's membrane of the macular area was performed in 12 human eyes, from newborn to 77-year-old subjects. In all the eyes examined the choriocapillary endothelial cells were observed to project pseudopodia through defects in the endothelial basement membrane. The frequency of pseudopodia oriented to the retinal pigment epithelial cell side was significantly larger than those projected from the lateral side of the choriocapillaris or oriented to the choroidal side. Deposits in Bruch's membrane increased along with age, and, even in young eyes, deposits of vesicular and tube-like structures were observed in the outer collagenous zone of Bruch's membrane. Choriocapillary endothelial pseudopodia might be related to the deposit formation in Bruch's membrane, especially the vesicular or tube-like deposit structures.
对12只人眼的黄斑区布鲁赫膜进行了电子显微镜观察，这些人眼的年龄从新生儿到77岁不等。在所有检查的眼睛中，均观察到脉络膜毛细血管内皮细胞通过内皮基底膜的缺陷伸出伪足。朝向视网膜色素上皮细胞侧的伪足频率明显高于从脉络膜毛细血管侧面伸出或朝向脉络膜侧的伪足频率。布鲁赫膜中的沉积物随年龄增加，即使在年轻的眼睛中，也在布鲁赫膜的外胶原区观察到囊泡状和管状结构的沉积物。脉络膜毛细血管内皮伪足可能与布鲁赫膜中的沉积物形成有关，尤其是囊泡状或管状沉积物结构。
