Yamamoto T, Fukuda S, Obata H, Yamashita H
Department of Ophthalmology, Tokyo Kohsei Nenkin Hospital.
Jpn J Ophthalmol. 1994;38(2):129-38.
The choriocapillary endothelial cells project pseudopodia-like processes (pseudopodia) through defects in the basement membrane in eyes without any insult or new vessel formation. The ultrastructure of these pseudopodia was observed by transmission and scanning electron microscopy. The pseudopodia contained microfilaments, ribosome-like organella, and/or endoplasmic reticulum-like organella; about half of the pseudopodia contained bundles of microfilaments, and 10% of these contained cytoplasmic organella. The frequency of pseudopodia was not correlated with age, sex, racial difference, location in ocular fundus, or age-related changes in Bruch's membrane. The results of this study did not reveal a relationship between pseudopodia and subretinal new vessel formation. Pseudopodia oriented toward the retinal pigment epithelium (RPE) were significantly more frequent than those oriented toward the choroid or projecting from the lateral side of the choriocapillaris, which suggests a close relationship between the pseudopodia and the function of the RPE.
在没有任何损伤或新生血管形成的眼睛中，脉络膜毛细血管内皮细胞通过基底膜的缺陷伸出伪足样突起（伪足）。通过透射电子显微镜和扫描电子显微镜观察这些伪足的超微结构。伪足含有微丝、核糖体样细胞器和/或内质网样细胞器；约一半的伪足含有微丝束，其中10%含有细胞质细胞器。伪足的出现频率与年龄、性别、种族差异、眼底位置或布鲁赫膜的年龄相关变化无关。本研究结果未揭示伪足与视网膜下新生血管形成之间的关系。朝向视网膜色素上皮（RPE）的伪足比朝向脉络膜或从脉络膜毛细血管侧面伸出的伪足明显更频繁，这表明伪足与RPE的功能密切相关。
