School of Pharmacy and ‡School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University , 800 Dongchuan Road, Shanghai 200240, China.
Chem Rev. 2016 Dec 14;116(23):14769-14827. doi: 10.1021/acs.chemrev.6b00564. Epub 2016 Nov 22.
Chiral cyclic structures are found in numerous natural products, pharmaceutical compounds, and important synthetic intermediates. Asymmetric hydrogenation, allowing for the preparation of these complex targets in an environmentally benign and efficient manner, has received much attention over the past few years. This review summarizes the advances in the construction of chiral heterocycles and carbocycles (including cyclic amines, ethers, alcohols, and alkanes) via the asymmetric hydrogenation of nonaromatic cyclic substrates (including prochiral cyclic imines, ketones, and alkenes) using appropriate transition-metal complexes.
手性环状结构存在于许多天然产物、药物化合物和重要的合成中间体中。不对称氢化可以以环境友好和高效的方式制备这些复杂的目标物，因此在过去几年中受到了广泛关注。本文综述了使用适当的过渡金属配合物，通过非芳环环状底物（包括前手性环状亚胺、酮和烯烃）的不对称氢化反应，构建手性杂环和碳环（包括环状胺、醚、醇和烷烃）的进展。
