荨麻叶的化学成分、植物化学组成、抗氧化和抗炎活性
Chemical composition, phytochemical constituents, antioxidant and anti-inflammatory activities of Urtica urens L. leaves.
作者信息
Mzid Massara, Ben Khedir Sameh, Bardaa Sana, Sahnoun Zouheir, Rebai Tarek
机构信息
a Laboratory of Histology Embryology and Reproductive Biology, Faculty of Medicine of Sfax , University of Sfax , Sfax , Tunisia and.
b Laboratory of Pharmacology , Faculty of Medicine of Sfax, University of Sfax , Sfax , Tunisia.
出版信息
Arch Physiol Biochem. 2017 May;123(2):93-104. doi: 10.1080/13813455.2016.1255899. Epub 2016 Dec 14.
OBJECTIVE
The aim of this study was to investigate the chemical composition and antioxidant properties of Urtica urens L.(Uu) as well as its anti-inflammatory effect on carrageenan (CARR)-induced paw oedema in rats.
METHODS
The leaves were extracted using ethanol (EtOH) and water. The extracts were analysed for proximate composition and antioxidant activity using standard chemical analysis methods.
RESULTS
The proximate analysis showed that Uu leaves contained appreciable percentages of dry mass, ashes, carbohydrates, proteins, lipids, sugars, anthocyanin, carotenoid and fibre. Results showed that EtOH extract contained the highest amount of total phenolics, flavonoids, tannins, ortho-diphenols and flavonols. It decreased the paw oedema after CARR administration, and ameliorated the activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and the malondialdehyde (MDA).
CONCLUSIONS
Uu displayed a high potential as a natural source of minerals, phytochemicals and antioxidant properties. EtOH extract exhibited a significant inhibition against CARR-induced inflammation.
目的
本研究旨在调查荨麻（Urtica urens L.，Uu）的化学成分、抗氧化特性及其对角叉菜胶（CARR）诱导的大鼠足爪水肿的抗炎作用。
方法
使用乙醇（EtOH）和水对叶片进行提取。采用标准化学分析方法对提取物的近似成分和抗氧化活性进行分析。
结果
近似分析表明，Uu叶片含有相当比例的干物质、灰分、碳水化合物、蛋白质、脂质、糖、花青素、类胡萝卜素和纤维。结果表明，EtOH提取物中总酚、黄酮、单宁、邻二酚和黄酮醇的含量最高。给药CARR后，该提取物可减轻足爪水肿，并改善过氧化氢酶（CAT）、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GPx）的活性以及丙二醛（MDA）含量。
结论
Uu作为矿物质、植物化学物质和抗氧化特性的天然来源具有很大潜力。EtOH提取物对CARR诱导的炎症具有显著抑制作用。
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