Busuttil Francesca, Rahim Ahad A, Phillips James B
1 Department of Pharmacology, UCL School of Pharmacy, University College London , London, United Kingdom .
2 Department of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, University College London , London, United Kingdom .
Stem Cells Dev. 2017 Feb 15;26(4):231-238. doi: 10.1089/scd.2016.0188. Epub 2017 Jan 11.
Despite a substantially increased understanding of neuropathophysiology, insufficient functional recovery after peripheral nerve injury remains a significant clinical challenge. Nerve regeneration following injury is dependent on Schwann cells, the supporting cells in the peripheral nervous system. Following nerve injury, Schwann cells adopt a proregenerative phenotype, which supports and guides regenerating nerves. However, this phenotype may not persist long enough to ensure functional recovery. Tissue-engineered nerve repair devices containing therapeutic cells that maintain the appropriate phenotype may help enhance nerve regeneration. The combination of gene and cell therapy is an emerging experimental strategy that seeks to provide the optimal environment for axonal regeneration and reestablishment of functional circuits. This review aims to summarize current preclinical evidence with potential for future translation from bench to bedside.
尽管对神经病理生理学的理解有了大幅提高，但周围神经损伤后功能恢复不足仍然是一个重大的临床挑战。损伤后的神经再生依赖于雪旺细胞，即周围神经系统中的支持细胞。神经损伤后，雪旺细胞呈现出促再生表型，支持并引导再生神经。然而，这种表型可能不会持续足够长的时间以确保功能恢复。含有能维持适当表型的治疗性细胞的组织工程神经修复装置可能有助于增强神经再生。基因治疗和细胞治疗的结合是一种新兴的实验策略，旨在为轴突再生和功能回路的重建提供最佳环境。本综述旨在总结当前具有从 bench 到 bedside 未来转化潜力的临床前证据。
