2000 - 2016年非洲育龄妇女2型糖尿病患病率：系统评价与荟萃分析方案

Prevalence of type 2 diabetes mellitus in women of childbearing age in Africa during 2000-2016: protocol of a systematic review and meta-analysis.

作者信息

Chivese Tawanda, Mahmoud Werfalli, Magodoro Itai, Kengne Andre P, Norris Shane A, Levitt Naomi S

机构信息

Chronic Disease Initiative for Africa, Department of Medicine, University of Cape Town, South Africa.

Faculty of Health Sciences, South Africa Medical Research Council Developmental Pathways for Health Research Unit, Department of Paediatrics, University of the Witwatersrand, Johannesburg, South Africa.

出版信息

BMJ Open. 2016 Dec 13;6(12):e012255. doi: 10.1136/bmjopen-2016-012255.

DOI:10.1136/bmjopen-2016-012255

PMID:27965249

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5168695/

Abstract

INTRODUCTION

African women of childbearing age are increasingly being exposed to risk factors for type 2 diabetes mellitus (T2DM), most particularly obesity. A differentiating feature of diabetes in women of childbearing age is that the disease may affect the mother and the developing fetus. Apart from mapping the extent of the problem, understanding the prevalence of T2DM in African women of childbearing age can help to galvanise targeted interventions for reducing the burden of T2DM. This is a protocol for a systematic review aiming to assess the prevalence of and risk factors for T2DM in women of childbearing age (15-49 years) in Africa.

METHODS AND ANALYSES

We will carry out a comprehensive literature search among a number of databases, using appropriate adaptations of the African search filter to identify diabetes prevalence studies, published from 2000 to 2016, among African women of childbearing age (15-49 years) according to the WHO definition. Full copies of articles identified through searches and considered to meet the inclusion criteria will be obtained for data extraction and synthesis. The analysis of the primary outcome (prevalent diabetes) will include two steps: (1) identification of data sources and documenting estimates and (2) application of the random-effects meta-analysis model to aggregate prevalence estimates and account for between-study variability in calculating the overall pooled estimates and 95% CI for diabetes prevalence. We will assess heterogeneity and publication bias using established methods. This systematic review will be reported according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses Protocol (PRISMA-P) 2015.

ETHICS AND DISSEMINATION

Ethical approval is not required for this study, given that this is a protocol for a systematic review, which utilises published data. The findings of this study will be widely disseminated through peer reviewed publications and conference presentations.

TRIAL REGISTRATION NUMBER

CRD42015027635.

摘要

引言

非洲育龄妇女越来越多地暴露于2型糖尿病（T2DM）的危险因素中，尤其是肥胖。育龄妇女糖尿病的一个区别特征是该疾病可能影响母亲和发育中的胎儿。除了明确问题的严重程度外，了解非洲育龄妇女中T2DM的患病率有助于推动针对性干预措施，以减轻T2DM的负担。这是一项系统评价方案，旨在评估非洲育龄（15 - 49岁）妇女中T2DM的患病率及其危险因素。

方法与分析

我们将在多个数据库中进行全面的文献检索，采用适用于非洲的检索过滤器，以识别2000年至2016年期间根据世界卫生组织定义的非洲育龄（15 - 49岁）妇女糖尿病患病率研究。将获取通过检索确定并被认为符合纳入标准的文章全文，以进行数据提取和综合分析。对主要结局（糖尿病患病率）的分析将包括两个步骤：（1）确定数据来源并记录估计值；（2）应用随机效应荟萃分析模型汇总患病率估计值，并在计算糖尿病患病率的总体合并估计值和95%置信区间时考虑研究间的变异性。我们将使用既定方法评估异质性和发表偏倚。本系统评价将按照2015年系统评价和荟萃分析优先报告项目声明（PRISMA - P）进行报告。