Department of Neurosurgery, University of Colorado-Anschutz Medical Center, Denver, Colorado, USA.
Department of Neurology, University of Colorado-Anschutz Medical Center, Denver, Colorado, USA.
J Neurol Neurosurg Psychiatry. 2017 May;88(5):445-451. doi: 10.1136/jnnp-2016-314471. Epub 2016 Dec 13.
Rapid eye movement (REM) sleep behaviour disorder (RBD) is characterised by complex motor enactment of dreams and is a potential prodromal marker of Parkinson's disease (PD). Of note, patients with PD observed during RBD episodes exhibit improved motor function, relative to baseline states during wake periods. Here, we review recent epidemiological and mechanistic findings supporting the prodromal value of RBD for PD, incorporating clinical and electrophysiological studies. Explanations for the improved motor function during RBD episodes are evaluated in light of recent publications. In addition, we present preliminary findings describing changes in the activity of the basal ganglia across the sleep-wake cycle that contribute to our understanding of RBD.
快速眼动 (REM) 睡眠行为障碍 (RBD) 的特征是梦境中的复杂运动表现，是帕金森病 (PD) 的潜在前驱标志物。值得注意的是，在 RBD 发作期间观察到的 PD 患者的运动功能相对于清醒期的基线状态有所改善。在这里，我们综述了支持 RBD 对 PD 的前驱价值的最近流行病学和机制发现，纳入了临床和电生理研究。根据最近的出版物，评估了 RBD 发作期间运动功能改善的解释。此外，我们还介绍了描述贯穿睡眠-觉醒周期的基底神经节活动变化的初步发现，这些发现有助于我们理解 RBD。
