Lee Shou-Wu, Lien Han-Chung, Lee Teng-Yu, Tung Chun-Fang, Yeh Hong-Zen, Chang Chi-Sen
Division of Gastroenterology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Department of Internal Medicine, Chung Shan Medical University, Taichung, Taiwan.
Gut Liver. 2017 May 15;11(3):377-382. doi: 10.5009/gnl16211.
BACKGROUND/AIMS: The aim of this study was to investigate the associations between obesity and erosive esophagitis (EE) or Barrett's esophagus (BE) in a Chinese population.
Data from subjects were retrospectively collected from 2006 to 2009. Individuals with BE were identified and age- and sex-matched at a 1:2 ratio with normal esophagocardial junction and EE patients. The subjects were stratified into two groups: the normal weight group and overweight/ obesity group (body mass index ≥25 mg/m²) or the normal waist group and abdominal obesity group (waist circumference ≥90 cm for men and ≥80 cm for women).
Overall, 45%, 72%, and 52% were overweight/obese and 23%, 65%, and 18% had abdominal obesity in the normal, EE, and BE groups, respectively. Positive associations were identified between EE and overweight/obesity (odds ratio [OR], 3.14; 95% confidence interval [CI], 1.75 to 5.66) and abdominal obesity (OR, 6.22; 95% CI, 3.34 to 11.57); however, the associations were nonsignificant between BE and overweight/obesity (OR, 1.32; 95% CI, 0.67 to 2.61) or abdominal obesity (OR, 0.73; 95% CI, 0.31 to 1.73). Female BE patients had a significantly increased rate of being overweight/obese.
Obesity is a contributing factor in EE. The association of BE and obesity was not significant, with the exception of female BE cases.
背景/目的：本研究旨在调查中国人群中肥胖与糜烂性食管炎（EE）或巴雷特食管（BE）之间的关联。
回顾性收集2006年至2009年受试者的数据。识别出患有BE的个体，并按1:2的比例与食管心交界处正常的个体和EE患者进行年龄和性别匹配。受试者被分为两组：正常体重组和超重/肥胖组（体重指数≥25mg/m²），或正常腰围组和腹型肥胖组（男性腰围≥90cm，女性腰围≥80cm）。
总体而言，正常组、EE组和BE组中分别有45%、72%和52%的人超重/肥胖，以及23%、65%和18%的人有腹型肥胖。EE与超重/肥胖（比值比[OR]，3.14；95%置信区间[CI]，1.75至5.66）和腹型肥胖（OR，6.22；95%CI，3.34至11.57）之间存在正相关；然而，BE与超重/肥胖（OR，1.32；95%CI，0.67至2.61）或腹型肥胖（OR，0.73；95%CI，0.31至1.73）之间的相关性不显著。女性BE患者超重/肥胖的发生率显著增加。
肥胖是EE的一个促成因素。除女性BE病例外，BE与肥胖之间的关联不显著。
