Wu Pin-Chieh, Chen Yan-Hua, Wu Fu-Zong, Lin Kung-Hung, Hsu Chiao-Lin, Chen Chi-Shen, Chen Yu-Hsun, Lin Po-Hsiang, Mar Guang-Yuan, Yu Hsien-Chung
Health Management Center, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, Republic of China.
Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, Republic of China.
Therap Adv Gastroenterol. 2019 Jun 3;12:1756284819853115. doi: 10.1177/1756284819853115. eCollection 2019.
Barrett's esophagus (BE) is a premalignant condition with increased incidence worldwide both in old and young individuals. However, the role of certain potential risk factors remains unclear in young adults (< 50 years). We aimed to determine the risk factors of BE in young adults.
A total of 4943 young adults who underwent upper gastrointestinal endoscopy at our health check-up center were enrolled. The diagnosis of BE was based on histological confirmation. We analyzed demographic factors, laboratory data, potential risk factors such as smoking, alcohol consumption, presence of gastroesophageal reflux disease (GERD) symptoms, and metabolic syndrome for the risk of BE by using binary logistic regression analysis.
The prevalence of BE was 1.8% (88/4943). Male sex, the presence of GERD symptoms, and smoking were three significant risk factors related to BE. Furthermore, participants who had smoked for 10 pack-years or more had increased risk of BE with dose-dependent phenomenon ( trend < 0.001). The proportion of BE in male participants with both GERD symptoms and a smoking history of 10 pack-years or more was as high as 10.3% (16/155).
Significant risk factors of BE in young adults are male sex, the presence of GERD symptoms, and smoking. The risk also increases with an increase in cumulative exposure to smoking.
巴雷特食管（BE）是一种癌前病变，在全球范围内，无论老年人还是年轻人，其发病率均呈上升趋势。然而，某些潜在风险因素在年轻成年人（<50岁）中的作用仍不明确。我们旨在确定年轻成年人患BE的风险因素。
共有4943名在我们健康体检中心接受上消化道内镜检查的年轻成年人纳入研究。BE的诊断基于组织学确认。我们通过二元逻辑回归分析，分析了人口统计学因素、实验室数据、吸烟、饮酒、胃食管反流病（GERD）症状以及代谢综合征等潜在风险因素与BE风险的关系。
BE的患病率为1.8%（88/4943）。男性、GERD症状的存在以及吸烟是与BE相关的三个重要风险因素。此外，吸烟达10包年及以上的参与者患BE的风险增加，且存在剂量依赖现象（趋势<0.001）。同时有GERD症状且吸烟史达10包年及以上的男性参与者中，BE的比例高达10.3%（16/155）。
年轻成年人患BE的重要风险因素为男性、GERD症状的存在以及吸烟。风险也随着吸烟累积暴露量的增加而增加。
